Search Skin Biology

Hydrogels for Osteochondral
Tissue Engineering
Journal of Biomedical

(March 2020)
Anti-Wrinkle Activity
& Transdermal Delivery
of GHK Peptide
Journal of Peptide Science
(March 2020)
Pulsed Glow Discharge
to GHK-Cu Determination
International Journal
of Mass Spectrometry

(March 2020)
Protective Effects of GHK-Cu
in Pulmonary Fibrosis
Life Sciences
(January 2020)
Anti-Wrinkle Benefits
of GHK-Cu Stimulating
Skin Basement Membrane
International Journal of Molecular Sciences
(January 2020)
Structural Analysis
Molecular Dynamics of
Skin Protective
TriPeptide GHK
Journal of Molecular Structure
(January 2020)
In Vitro / In Vivo Studies
pH-sensitive GHK-Cu in
Superabsorbent Polymer
GHK Enhances
Stem Cells Osteogenesis
Acta Biomaterialia
Antibacterial GHK-Cu
Nanoparticles for
Wound Healing
Particle & Particle (2019)
Effect of GHK-Cu
on Stem Cells and
Relevant Genes
OBM Geriatrics
GHK Alleviates
Neuronal Apoptosis Due
to Brain Hemorrhage
Frontiers in Neuroscience
Endogenous Antioxidant
International Journal of Pathophysiology and Pharmacology (2018)
Regenerative and
Protective Actions of
GHK-Cu Peptide
International Journal of
Molecular Sciences
Skin Regenerative and
Anti-Cancer Actions
of Copper Peptides
GHK-Cu Accelerates
Scald Wound Healing
Promoting Angiogenesis
Wound Repair and

GHK Peptide Inhibits
Pulmonary Fibrosis
by Suppressing TGF-β1
Frontiers in Pharmacology
Skin Cancer Therapy
with Copper Peptides
The Effect of Human
Peptide GHK Relevant to
Nervous System Function
and Cognitive Decline
Brain Sciences (2017)
Effects of Tripeptide
GHK in Pain-Induced
Aggressive Behavior
Bulletin of Experimental
Biology & Medicine
GHK-Cu Elicits
In Vitro Alterations
in Extracellular Matrix
Am Journal of Respiratory
and Critical Care Medicine

Selected Biomarkers &
Copper Compounds
Scientific Reports

GHK-Cu on Collagen,
Elastin, and Facial Wrinkles
Journal of Aging Science
Tri-Peptide GHK-Cu
and Acute Lung Injury

Effect of GHK Peptide
on Pain Sensitivity
Experimental Pharmacology

New Data of the
Cosmeceutical and
TriPeptide GHK
SOFW Journal
GHK Peptide as a
Natural Modulator of
Multiple Cellular Pathways
in Skin Regeneration
BioMed Research (2015)
Resetting Skin Genome
Back to Health
Naturally with GHK
Textbook of Aging Skin
GHK-Cu May Prevent
Oxidative Stress in Skin
by Regulating Copper and
Modifying Expression of
Numerous Antioxidant Genes Cosmetics (2015)
GHK Increases
TGF-β1 in
Human Fibroblasts

Acta Poloniae

The Human Skin Remodeling Peptide Induces Anti-Cancer
Expression and DNA Repair Analytical Oncology
Resetting the
Human Genome to Health
BioMed Research
Enhanced Tropic Factor Secretion of Mesenchymal
Stem Cells with GHK
Acta Biomater
Anxiolytic (Anti-Anxiety)
Effects of GHK Peptide
Bulletin of Experimental
Biology & Medicine
Lung Destruction and
its Reversal by GHK
Genome Medicine
TriPeptide GHK Induces
Programmed Cell Death
of Neuroblastoma
Journal of Biotechnology
Stem Cell
Recovering Effect
of GHK in Skin
Peptide Science
Skin Penetration of
Copper Tripeptide in Vitro
Journal of International
Inflammation Research
Possible Therapeutics
for Colorectal Cancer
Journal of Clinical and
Experimental Metastasis
Methods of Controlling
Differentiation and
Proliferation of Stem Cells
Effects of
Copper Tripeptide
on Irradiated Fibroblasts
American Medical Association
Avoid Buying Fake Copper Peptides Dangerous

How Sensitive Is Your Skin?


You've tried everything! Products for sensitive skin, hypo-allergenic cosmetics, botanical oils and 100% natural, organic products and yet found no relief. Creams and serums that looked so soft and silky while in the jar inevitably turn into stinging, burning, irritating and drying concoctions the moment they touch your skin. Even plain water and soap often leave an unpleasant sensation, causing reddening, itch and scaling. The epidemic of global warming does not just affect the environment; toxic sunscreens leave bumps and blisters on delicate skin. Knowing what to put on your skin and what to avoid is vital if you ever wish to ameliorate this concern.

Approximately 40% of the population believes that they have sensitive skin. Even though a small percentage of those who experience adverse reactions to cosmetic products have allergies; in most cases, dermatologists cannot find any pathology behind those reactions. A doctor may perform a patch test on your skin to help determine the cause of irritation; on the other hand, you may visit your doctor and he or she concludes that “It is all in your head." That, of course, doesn’t mean that your unpleasant symptoms will magically disappear. Your skin still needs help. Oftentimes, looking for skin products that lack artificial fragrance and display a shorter list of ingredients on the label is a good place to start. You may switch to a dye and fragrance free laundry detergent or one that is formulated for infants.

The following conditions may lead to skin sensitivity:

Atopic dermatitis (Eczema)

Dry skin (or sensitivity induced by prescription retinoids, over washing, or harsh solvents such as alcohol or acetone)

Diabetic skin problems



Practical Solutiuns for Skin Conditions

Step-by-Step Sensitive Skin Help

Sensitive skin requires you to be alert to its needs and nurture it as a delicate flower.

  • Step One: Avoid factors that may further disrupt your protective barrier. Wash your skin no more than two times a day, using mild skin cleanser and warm water. Use a cleanser specially formulated for sensitive skin with pH 5.5-7.5 (from slightly acidic to neutral). Most commercial soaps are alkaline with a pH 9-10 and will cause more irritation.

  • Step Two: After washing, apply a light layer of squalane or emu oil – these natural lipids replenish skin oil safely, preventing water loss and irritation. Emu oil has healing properties and was long used by Australian indigenous people to heal wounds and insect bites. Rich in unsaturated fatty acids, emu oil penetrates skin deeply to powerfully deliver moisture and heal from within. Squalane is a luxuriously light lipid that absorbs instantly and can be safely and ethically harvested from olives. Natural skin oils are multipurpose; they strengthen your skin's protective barrier while replenishing your skin with fatty acids and antioxidants, softening its appearance and slowing the aging process.

  • Step Three: Exfoliate your skin once to twice a week to increase cell turnover. Use only mild exfoliators, containing lactic acid. Don’t forget to assist your skin's healing ability with Emu oil after exfoliation.

  • Step Four: To support skin regeneration, use cosmetic products containing copper-peptides. The first copper peptide, GHK-Cu, was discovered by Dr. Loren Pickart in his age-defying experiments. Copper peptides assist skin regeneration, speed up cell turnover, boost antioxidant and immune defense, reduce inflammation and help reduce visible signs of irritation such as swelling and redness. Recent studies show that the copper peptide GHK-Cu is also capable of regulating gene function by enhancing skin protective proteins and improving the skin's system of waste disposal that eliminates damaged and altered proteins preventing their accumulation. Since not all copper peptides possess skin regenerating properties, be sure to do your research thoroughly before buying.

  • By carefully nurturing your skin and restoring its own protective system, you can significantly improve the appearance of sensitive skin, reduce discomfort and dryness, eliminate itching and burning and finally enjoy smooth, resilient, youthful looking and radiantly beautiful skin.

    Problem #1 Disrupted Skin Barrier

    Your skin is naturally protected from environmental assaults by a special structure called the epidermal barrier. It is located in the upper layers of your skin and consists of many layers of hard, keratinous scales, attached to each other.

    To add softness and to protect our skin from water loss, the keratinous scales are glued together with special oils – a mixture of ceramides, cholesterol and free fatty acids. In addition, the skin's surface is covered with a different kind of oil called sebum.

    While too much sebum gives skin a shiny and greasy appearance and may cause acne, the right amount of this natural lubricant makes skin soft and smooth.

    When the skin barrier is undisturbed, it effectively prevents water loss as well as protects the skin from irritating and damaging substances. Unfortunately, it developed millions of years ago, long before humans invented soap. Many people find usage of normal bar soap intolerable; rash associated with soap sensitivities can cause an unpleasant heat sensation in the affected area of ​​skin.

    As it turns out, alkaline soap and hot water manage to disturb the skin barrier by washing away skin protective oils and loosening keratinous scales; they also drastically change the pH of the outer layer of skin. It takes hours for it to return to its normal acidity. Most bar soaps have pore clogging and irritating chemicals in their formulation. Problems such as dermatitis, eczema, and sensitivity rashes could be solved by switching your soap to a pH-correct cleanser. When we are young, skin is very prompt in restoring the damage we unknowingly cause, but as we grow older, it becomes more and more difficult for it to recover from these assaults. When damage to the barrier becomes chronic, skin responds with inflammation, itching and swelling in its futile attempts to restore balance.

    In addition, toxic and irritating substances from skin products such as fragrances and synthetic colors can enter the skin and cause even more damage. Unfortunately, cosmetic manufacturers are allowed to use such chemicals on the assumption that they won’t penetrate the skin. A visit to EWG Skin Deep database often produces shocking results when common cosmetics' ingredients are reviewed. Have you checked to see how safe your products are?

    Layers of Skin

    Problem #2 Loss of Skin Oil

    Many teenagers cannot wait until they become older to stop suffering from acne.

    Yes, it is true. As we grow older, oil glands start producing less oil, reducing acne, but making skin drier and more sensitive. The most important component of skin oil is squalane – a colorless, odorless compound with legendary healing powers that makes our skin soft and supple, while protecting it from damage.

    With less squalane, the skin becomes dry, rough and prone to irritation, and when skin cells aren't plump, temporary wrinkles may form.

    Problem #3 Loss of Skin Regenerating Molecules

    Do you remember how your skin looked when you were a child? Smooth like a balloon, plump with healthy moisture, strong and resistant. You could cover it with dirt or sweets; you could expose it to sun and wind, and yet it remained unscathed. When you grazed it, it would heal fast and without scars. When you were a teen, you could wash your face with harsh soap, go to sleep with your makeup still on, and use alcohol-based cleansers several times a day.

    Your skin could keep building and rebuilding such a strong barrier because of an excellent cell turnover rate – a sign of skin health is the constant flow of cells from lower to upper layers. As old cells turn into dry keratinous scales and exfoliate, new cells take their place, keeping the skin resilient, youthful and radiant. However, as we grow older, the skin’s regenerative power withers, its protective fortress weakens, and you begin experience more and more skin rashes, irritation and redness. The conscientious consumer searches for a product with a powerful antioxidant that can diminish signs of premature aging and effectively soothe aggravated skin.

    As we now know, the main reason behind such progressive loss of skin regenerative power is gradual decline of skin regenerative compounds and youth-sustaining factors in blood – in particular, the natural skin protective copper peptide, GHK-Cu, which plays a role in keeping tissue youthful and skin aesthetically pleasing. As experiments show, the addition of GHK can boost skin regenerative power by awakening its stem cells. The Journal of Peptide Science declares, after a peer-reviewed study, that "GHK increased the stemness and proliferative potential of epidermal basal cells". GHK-Cu has been also shown to repair DNA in damaged skin fibroblasts – the main collagen building cells, slowing the cellular degradation that comes with aging. Read the table below to better understand how GHK helps clients with safe, simple solutions to recapture their youth.

    How Copper May Aid Skin Health Based on Published Studies

    Healthful Action

    Acts by:

    Effect on Skin

    Anti-inflammatory and anti-oxidant

    1. Increases production of the antioxidant proteins Superoxide Dismutase and Decorin

    2. Decreases production of TGF-beta and TNF-alpha, and scarring caused by TGF-beta1, and skin damage by interleukin-1

    3. Neutralizes oxygen free radicals and reactive carbonyl species

    4. Blocks ultraviolet radiation damage to keratinocytes and recovery from X-rays damage to fibroblasts

    Calmer skin. Less Irritation.
    Less scar formation.

    Removes damaged skin and proteins

    1. Activate metalloproteinases
    Removal of damaged proteins, damaged skin,
    and skin blemishes

    Rebuilding skin

    1. Helps increase the synthesis of new collagen, elastin, and water-holding proteoglycans

    2. Aids in rebuilding the blood's microcirculation

    3. Repairs and tightens skin barrier

    4. Increases production of new skin fibroblasts and keratinocytes

    Firmer, tighter,
    better-looking skin.
    Better moisturized skin.
    More resistance to entry of
    viruses and bacteria.

    Studies on Dr. Pickart's skin remodeling
    copper peptides

    Publications from over 80 leading Universities and Medical Research Institutes by leading dermatologists and scientists

    For more on the studies, visit


    The information provided on this website is for educational purposes only.
    Any suggestions mentioned are not for the treatment or prevention of any skin disease or condition.
    If you have a special skin concern, please consult a physician or dermatologist first.

    Questions or Advice?

    Ask Dr. Loren Pickart:

    Call us at 1-800-405-1912 Monday through Friday (8 am to 6 pm) PST

    revised 7/1